Chuba Hubbard rushed for a career-high 256 yards and three touchdowns, and Oklahoma State defeated Tulsa 40-21 on Saturday afternoon.
Hubbard ripped off touchdown runs of 75 and 30 yards in the first four minutes of the game.
His first score came on the first play from scrimmage, 10 seconds into the contest.
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"He was awesome," Oklahoma State quarterback Spencer Sanders said. "The first play of the game -- that was such a confidence booster. It's awesome to hand somebody the ball that can do that."
The Cowboys (3-0) opened up a 17-0 lead before Tulsa recovered. The Golden Hurricane took a 21-20 lead on a 1-yard touchdown run by Shamari Brooks late in the first half.
Oklahoma State star receiver Tylan Wallace was bottled up for much of the game, but broke loose for a 90-yard touchdown reception late in the third quarter -- the third longest scoring connection in school history -- to give the Cowboys a 33-21 lead. He finished with five catches for 118 yards.
Oklahoma State outscored Tulsa 20-0 in the second half.
"We were just shooting ourselves in the foot," Hubbard said. "I felt that we should have been ahead by a lot more. Just mental errors that we've got to fix, but in the second half, we had a lot of leadership in the locker room and talked about how we've got to come out and just hit them again how we did the first play. And we did that."
It was Oklahoma State's first game since billionaire booster T. Boone Pickens died on Wednesday. He donated more than $650 million to the school, and the football stadium is named for him. The Cowboys wore stickers with "Boone" on the back of their helmets in his honor.
Brooks ran for 107 yards and two touchdowns and Keylon Stokes had seven catches for 109 yards and a score for Tulsa (1-2).
Oklahoma State: The Cowboys learned that Hubbard can carry the team and that they can win without a dominant performance by Wallace. It was Hubbard's second game this season with at least 200 yards rushing -- he had 227 yards against Oregon State in the opener.
Tulsa: The Golden Hurricane were overpowered in the second half and finally lost track of Wallace for the backbreaking touchdown in the third quarter. But the Golden Hurricane stood toe-to-toe for most of the game with a solid Power Five team that was receiving Top 25 votes.
Oklahoma State will play at Texas on Saturday.
Tulsa will host Wyoming on Saturday.