Texas Tech got an errorless performance out of a true freshman quarterback making his second career start. No turnovers, though, couldn't overcome a porous rush defense.
Patrick Mahomes played in place of Davis Webb, who is still recovering from a high-ankle sprain.
The 42-30 loss to Oklahoma on Saturday assured the Red Raiders of not reaching six wins and bowl eligibility. It was their third-straight loss.
"You wanted somebody that could move around," Texas Tech Kliff Kingsbury said. "I knew we'd have a hard time up front protecting so I felt like Pat, his mobility gave us a better shot and didn't want to put Davis out there unless he was 100 percent. I thought Pat did some good things, protecting the ball. That's what I asked him to do."
Samaje Perine scored three touchdowns and Cody Thomas threw for one score and ran for another to lead Oklahoma.
The win kept OU coach Bob Stoops from consecutive losses for the first time since 1999.
Perine scored touchdowns from 2, 64 and 11 yards. It was the true freshman's second 200-yard performance. He finished with 213 yards on 25 carries.
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Thomas, who was in for injured starter Trevor Knight, threw a 3-yard pass to Neal Durron. Thomas recovered after halftime following three interceptions in the first half.
Aaron Ripkowski scored on a 1-yard run to seal the win for the Sooners (7-3, 4-3 Big 12).
Texas Tech has given up 11 individual 100-yard rushers this season, including two each against Arkansas, West Virginia, TCU and Oklahoma.
Next up for the Red Raiders is Iowa State. They close the season against Baylor.
"You just got to keep pushing through the rest of the season," Red Raiders linebacker Sam Eguavoen said. "We can't make it get any uglier. We just got to keep fighting."
Backup quarterback Patrick Mahomes threw for four touchdowns to lead Texas Tech (3-7, 1-6).
The Sooners scored touchdowns on each of their five second-half drives.
Perine now has 1,001 yards for the season and is the first Sooner since DeMarco Murray in 2010 to get 1,000 yards in a season. It was the first time a freshman has rushed for more than 1,000 yards since Adrian Peterson in 2004. Perine is only the fifth rusher in school history to cross the 1,000-yard mark.
As they have all season, penalties hurt Texas Tech. They finished with 9 penalties for 85 yards, including a touchdown that was called back because of a holding penalty midway through the third quarter.
The teams traded touchdowns after halftime. Mahomes got his third touchdown when he rolled to his left and found Devin Lauderdale along the near sideline for a 75-yard score. The Sooners didn't take long to answer. Perine went around end and outraced Red Raiders defenders for a 64-yard touchdown to pull within 21-14.
It was the first time in 18 games that Texas Tech won the turnover battle. The Red Raiders didn't turn the ball over.
The Red Raiders, who led 14-7 at halftime, failed to get any points off three interceptions from Cody Thomas. They punted on the first, missed a 48-yard field goal and the third ended the half when Keenon Ward was shoved out of bounds as the half ended.
The last time the Sooners had three picks in a half was in 2010 when Landry Jones threw three against Oklahoma State. Stoops said Thomas is resilient.
"We've seen it, he carries himself that way," he said. "He doesn't lack for confidence and, the way he presents it, it's the right way. I'm happy it turned out the way it did. He made a lot of great decisions there in the second half."
Texas Tech scored first when Mahomes found Jakeem Grant for a 6-yard score. It was the Red Raiders' longest drive of the season at 7:05.
The first quarter ended without a score by the Sooners, their fourth straight scoreless quarter.
