October 21, 2011 6:24 pm Big Game Friday Night – 5pm – Oct. 21, 2011 NBC 5’s Rontina McCann is live as undefeated DeSoto High School wears pink for breast cancer awareness when they take on Mesquite Horn for Big Game Friday Night. Wake Up to Something Good 0:49 5 things to know about Mike Trout 0:57 2024 Kentucky Derby: What to know, horses, prize money 0:41 MLB will reportedly modify uniforms by 2025 after player complaints 0:45 Where will the 2025 NFL draft take place? 1:23 NFL draft prospects continuing family legacies