A wrong-way crash closed eastbound state Highway 121 in Haltom City for several hours Monday morning.
It happened on SH121 on the bridge crossing Haltom Road.
Police said the driver of a black Honda was going the wrong way on SH121 and crashed head-on into a silver Honda SUV.
A man in the black Honda and a woman in the silver SUV were taken to the hospital in unknown conditions.
Two other vehicles were also involved in the crash, but with far less damage.
Haltom City police are still investigating.
The highway was closed for more than four hours and reopened just before 6 a.m.