A semitrailer carrying acetone overturned Wednesday night on eastbound Interstate 20 near Bonnie View Road in Dallas.
Dallas County Sheriff Deputies said somehow the 18-wheeler crashed, skidded through a side barrier and then flipped on its side.
At least two other vehicles were involved in the crash.
A full hazmat crew responded to the scene and was working to make sure the acetone, a type of paint thinner, stays contained.
Crews told NBC 5 they plan to transfer the liquid inside the 18-wheeler to another truck before turning it upright.
Eastbound traffic on the highway was down to one lane.
Paramedics transported at least three people to Baylor Medical Center.
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Deputies said all of the injured people are expected to be recover.
