Samaje Perine ran for 201 yards and four touchdowns and helped quarterback Baker Mayfield top his old team as No. 17 Oklahoma defeated Texas Tech 63-27 on Saturday.
Mayfield transferred from Tech after his freshman season in 2013 and had to sit out last year because the school blocked him from playing right away.
Mayfield completed 15 of 22 passes for 212 yards and two touchdowns. Joe Mixon ran for 154 yards and two scores, and the Sooners (6-1, 3-1 Big 12) ran for 405 yards.
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Texas Tech quarterback Patrick Mahomes passed for 233 yards and ran for 58, but threw four interceptions. DeAndre Washington ran for 94 yards and a touchdown for the Red Raiders (5-3, 2-3).
Mayfield walked on and started at Tech two years ago before losing the job, and he transferred because he believed Tech had no plans to offer him a scholarship. In his first game against his former team, he helped the Sooners gain 617 total yards.
It was the fourth 200-yard game of Perine's career, and the most yards for the sophomore since he set the FBS record with 427 yards last season against Kansas.
Oklahoma jumped to a 21-3 lead, but two turnovers by the Sooners became scores for the Red Raiders. Reginald Davis caught a 6-yard touchdown pass from Mahomes, and Washington scored from 13 yards out to bring the Red Raiders back.
Perine rumbled in from 10 yards out to give the Sooners a 28-17 lead at halftime. He ran for 132 yards and two touchdowns before the break, and Mixon added 67 yards and two scores.
Mark Andrews caught a 13-yard touchdown pass from Mayfield to make it 35-17. Perine got loose again for a 48-yard run and closed the drive with a six-yard score. The Sooners took a 49-27 lead into the fourth quarter.
About the only negative in the game for the Sooners came early when cornerback Zack Sanchez left in the first quarter with a right leg injury. Sanchez, an All-Big 12 selection last year, was carted off and returned to the sideline later in the quarter with an air cast.