Hamilton hit a towering drive off the left-field wall for a triple in the bottom of the first.
He jogged out to center field between innings but retreated to the dugout before the inning started, departing with tightness in his right Achilles' tendon.
Hamilton walked to the Rangers right-field clubhouse, where he was examined by team physicians. Manager Ron Washington says he'll give Hamilton the day off today -- ahead of tomorrow's scheduled day off and re-evaluate after that.
Connecting you to your favorite North Texas sports teams as well as sports news around the globe.
Chris Woodward and Chris Shelton homered for the Mariners, who are unbeaten in their first four Cactus League games.
Rangers starter Vicente Padilla allowed four first-inning runs. He settled down in the second and struck out two in his first spring appearance.
-- Hamilton is 5-for-9 with two homers, a triple and four RBIs in four games this spring.
-- Rangers rightfielder Marlon Byrd made his spring debut following offseason microfracture surgery on his left knee and went 0-for-2 with a walk.
-- Rangers shortstop Omar Vizquel provided the game's defensive highlight in the seventh, moving to his left and making a barehanded grab back to his right off a bad hop before throwing Prentice Redman out at first.