"The American people have spoken and spoken clearly."
He delivered the speech at about 11: 15 p.m. EST, to a large crowd, which booed when Obama's name was mentioned, and alternately chanted "U-S-A" and "John McCain."
McCain blamed himself for the loss and thanked his running mate, Alaska Governor Sarah Palin, "one of the best campaigners I've ever seen."
He also said, "I don't know what more we could have done," and called the campaign, "the great honor of my life."
McCain — with wife Cindy on one side and Palin on the other — urged his supporters to put aside partisan differences and work to get "the country moving again."
He told his his supporters, "It's natural tonight to feel some disappointment. Though we fell short, the failure is mine, not yours."