Two people were also injured in the multivehicle wreck that shut down Interstate 35 for seven hours.
The crash occurred at about 11:55 a.m. in the northbound lanes at the Elm Creek bridge near FM 1306, where bridge maintenance had narrowed the two lanes to one.
DPS Trooper Mark Tackett said an 18-wheeler driver by James Crayton, of Dallas, apparently did not slow before it hit the first vehicle. The car exploded on impact, killing Anthony and Kimberly Brandon, of Bedford.
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Crayton's truck then slammed into a Honda Accord driven by Carol Whaley, 63, of Yalaha, Fla., injuring him and his wife, Linda, 61.
The 18-wheeler then hit another vehicle, ramming it into the rear of another 18-wheeler. The driver of that vehicle, Darryl Hoosier, 55, of Lafayette, La., was killed.
The driver of the second truck was not injured.
Carol Whaley is listed in fair condition at a Fort Worth hospital. His wife was treated at a Gainesville hospital and released.
Crayton, 59, suffered minor injuries and was transported to a hospital for testing and questioning.
The truck he was driving is registered to Bradco Supply.