Elijah Stewart hit a late 3-pointer for No. 11 seed Southern California as the Trojans upset sixth seeded SMU 66-65 Friday in the first round of the NCAA Tournament.
SMU's Shake Milton missed a floater at the buzzer.
Stewart had 22 points for the Trojans (26-9). Bennie Boatright and Chimezie Metu each added 14 for USC, which advances to play Baylor in the second round of the East region on Sunday.
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Semi Ojeleye had 24 points and 10 rebounds and Sterling Brown had 17 points for SMU (30-5), which had won 16 straight.
SMU was in the NCAA Tournament after being banned from postseason play a year ago for multiple violations, including academic fraud and unethical conduct.
USC: USC also rallied from a big deficit in the second half in its First Four win over Providence on Wednesday night. Against SMU, the Trojans trailed by 10 in the second half.
SMU: Getting back to the NCAA Tournament was a big deal for the Mustangs, who qualified in 2015. SMU won the American Athletic Conference regular season and postseason titles.
USC: Will play Baylor Sunday in the second round.
SMU: Season over.