Starting Friday night, two lanes of eastbound Interstate 635 will be closed from Preston Road to Park Central Drive.
The lanes will re-open Monday at 5 a.m.
An HOV connector ramp from eastbound LBJ TEXpress Lanes on I-635 to northbound US 75 will be open during the closure to help with traffic.
TEXpress lanes from Luna Road to Greenville Avenue will be free to use during this closure, officials say.
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The closures are part of a $2.6 billion LBJ Express project.
There will be additional closures the following weekend.