Starting Friday night, two lanes of eastbound Interstate 635 will be closed from Preston Road to Park Central Drive.
The lanes will re-open Monday at 5 a.m.
An HOV connector ramp from eastbound LBJ TEXpress Lanes on I-635 to northbound US 75 will be open during the closure to help with traffic.
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TEXpress lanes from Luna Road to Greenville Avenue will be free to use during this closure, officials say.
The closures are part of a $2.6 billion LBJ Express project.
There will be additional closures the following weekend.