Jennifer Hide shot a 1-under 71 to help three-time defending women's champion Bethune-Cookman open a 24-stroke lead in the PGA Minority Collegiate Golf Championship.
The Wildcats had a 13-over 589 total at PGA Golf Club. They are seeking their 12th title.
"They did well, everyone is contributing," Wildcats coach Loritz "Scooter" Clark said. "We hope to keep it going just one more day. For them to be able to win would be a huge accomplishment. It would be historical. I am so proud of all of them, especially my three seniors."
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Houston-Victoria was second.
The Alabama State men took a 14-stroke lead over first-round leader Florida A&M. The Hornets had a 16-over 592 total, with Branson Ferrier following his opening 66 with a 70.