Ed Wesley rushed for 120 yards and two touchdowns and Waymon James added 181 yards on the ground to lead TCU over Wyoming 31-20 Saturday.
Despite committing five turnovers, including three in the red zone, TCU (7-2, 4-0 Mountain West) won its fourth game in a row.
The Horned Frogs also extended their record Mountain West win streak to 21 games and tied the league record for consecutive conference road wins at 11. BYU, which is no longer a member of the Mountain West, won 11 straight from 2005-07.
Matthew Tucker added 90 yards rushing and two TDs as TCU gained 390 yards on the ground. Casey Pachall completed 17 of 24 passes for 227 yards.
Brett Smith led Wyoming (5-3, 2-1) with 210 yards and two touchdowns passing and 68 yards rushing before leaving the game early in the fourth quarter after taking a hard hit from TCU's Tank Carder.
The loss ended Wyoming's two-game win streak and kept the Cowboys from their first 3-0 start in the Mountain West.
The last time Wyoming began a season 3-0 in conference play was 1998, when it was a member of the Western Athletic Conference and finished a game out of first place in the WAC Mountain Division.
The game was tied 17-17 at halftime after Wyoming defensive back Blair Burns intercepted a Pachall pass at the goal line with 30 seconds remaining in the second quarter. TCU, which had gone the previous two games without a turnover, also lost four fumbles, including two within Wyoming's 10-yard line in the second half.
TCU's first-half points came on a 5-yard run by Tucker, 2-yard run by Wesley and 35-yard field goal by Ross Evans.
The Cowboys scored on a 7-yard pass from Smith to Josh Doctson, an 18-yard pass from Smith to Mazi Ogbonna and a 33-yard field goal by Daniel Sullivan.
Wyoming opened the second half with 53-yard drive that resulted in a 48-yard field goal by Sullivan to take a 20-17 edge.
But TCU took the lead late in the third quarter with a 10-play, 80-yard drive that ended with Wesley scoring from 4 yards out.
The only score in the fourth quarter came on a 4-yard run by Tucker.