Oklahoma quarterback Sam Bradford, last season's Heisman winner, hasn't played since injuring his shoulder in the first game.
Florida quarterback Tim Tebow, the 2007 trophy winner, spent Saturday night in a hospital after a third-quarter concussion in the top-ranked Gators' win over Kentucky.
Other contenders such as California tailback Jahvid Best have been knocked down by a poor game. He had just 55 yards in a 42-3 loss to Oregon.
The worst thing to hit McCoy so far -- has been the flu.
McCoy was at full strength in Saturday's 64-7 win over Texas-El Paso, passing for 286 yards and three first-half TDs for the unbeaten No. 2 Longhorns.
UT's next game is Oct. 10 against Colorado.