U.S. Highway 75 in Collin County is open Tuesday morning after a wrong-way crash closed the highway for several hours.
Police said a man was driving north in the southbound lanes and slammed into a big-rig shortly before 1 a.m. near 75 and Melissa Road in Melissa.
The big-rig ended up on the opposite side of the highway after crossing a center media and barreling through a cable barrier.
The big-rig's driver was not seriously injured and was treated and released at the scene.
The driver of the car taken by air ambulance to a Plano hospital. His condition is not known.
Police have not yet said if the driver of the car will face any charges in connection with the crash.