The man crashed into the guardrail near the Green Oaks Boulevard entrance ramp at about 10:30 p.m. and was pronounced dead at the scene, police said.
Witnesses told police that the Mustang was speeding on the roadway before it lost control and crashed. However, at this point, it isn't clear whether wet roadways, speed or other circumstances caused the wreck, police said.
The accident remained under investigation Monday.
Police said two crashes involving other vehicles happened on the same roadway as others tried to avoid the wreck. None of those crashes resulted in serious injury, police said.