American Eagle notified Texas officials of possible furloughs for 223 employees in early 2012.
A letter sent to the Texas Workforce Commission said 119 pilots and 104 flight attendants in the Dallas-Fort Worth area could lose their jobs around Feb. 13, 2012.
The employees targeted work for Executive Airlines, which runs turboprop planes that may be phased out of American Eagle's flight operations as cost-cutting moves.
American Eagle and American Airlines parent company, AMR Corp. filed for bankruptcy protection in November.
"We will have to make very tough and sometimes unpopular decisions that will impact people's lives," new AMR CEO Thomas Horton told employees on Thursday.
Renegotiation with many pilots and flight attendants unions is expected to be a main portion of discussions surrounding cutting labor costs during bankruptcy proceedings.