Residents concerned about a possible cluster of cancer cases caused by drilling pollutants had urged the department to do the study.
"We found nothing in the data to indicate the community is at higher risk for these types of cancers," said health department epidemiologist Eric Miller.
The analysis examined rates of leukemia, non-Hodgkin's lymphoma, childhood brain cancer and female breast cancer in zip codes 75022 and 75028, which include Flower Mound.
The survey did find higher than normal rates of breast cancer, but the health department said population growth could have skewed the numbers.
Flower Mound had a population of 68,000 in 2007. But the study used census data from 2000, when the city's population was just 44,000, said health department spokeswoman Allison Lowery.
There is no established link between breast cancer and benzene, a chemical released in natural-gas drilling, she said.