The university will present LaBelle with the doctorate in humane letters at its May 13 commencement ceremony.
LaBelle's singing career has spanned more than four decades and includes several hit records and two Grammy Awards. She has also written four books, two of which are cookbooks.
LaBelle served as a spokeswoman for the American Diabetes Association after being diagnosed with the condition. Two years ago, she partnered with Temple to raise awareness about diabetes.
Temple President Ann Weaver Hart says in a statement Tuesday that the university is honoring LaBelle for "her professional excellence and her selfless service to others."
Related Content from AccessHollywood.com:
VIEW THE PHOTOS: Celebs Who Give Back
VIEW THE PHOTOS: The Latest Star Sightings
PLAY IT NOW: Kris Allen & 'American Idol' Give Back To Help Haiti Earthquake Victims
PLAY IT NOW: Patti LaBelle Honored At UNCF Evening Of Stars