The Spanish colonial revival home with four bedrooms and three bathrooms on 5th Helena Drive is where the actress died of an overdose of sleeping pills in 1962.
Built in 1929, the home and swimming pool are on 23,000 square feet of land, according to the website of David Offer of Prudential California Realty.
The house is behind tall gates on a cul de sac.
The website describes the home as a "sprawling and very special," and "the crown jewel and largest property of all the Helenas (one of Brentwood's most romantic and coveted locations) affording lovely vistas and great privacy & seclusion yet in close proximity to San Vicente shops & restaurants and the Sunday Farmer's Market."
Monroe died on Aug. 5, 1962, at age 36.
According to the Los Angeles Times, she had recently purchased the home for $75,000.