Both were ruled out by the team on Friday.
Alex Barron, acquired in the off season from the Rams will replace Colombo at right tackle. Montrae Holland will start in Kosier's place at left guard. Both have been seeing action in those spots since the starters went down with knee injuries a few days apart in mid-August.
Colombo was expected back by this week. Kosier could miss up to the first three games.